Medication Safety Issues
High alert medication:
The Institute for Safe Medication Practices (ISMP) includes this medication among its list of drug classes which have a heightened risk of causing significant patient harm when used in error.
Other safety concerns:
Interferes with hepatic synthesis of vitamin K-dependent coagulation factors (II, VII, IX, X)
Product Availability (US)
Not available in the US
Storage/Stability
Store at 15°C to 30°C (59°F to 86°F).
Adverse Reactions
As with all anticoagulants, bleeding is the major adverse effect of acenocoumarol. Hemorrhage may occur at virtually any site. Risk is dependent on multiple variables, including the intensity of anticoagulation and patient susceptibility. Frequency not defined.
Dermatologic: Skin necrosis (including hemorrhagic forms) (rare)
Genitourinary: Priapism
Hematologic & oncologic: Hemorrhage may occur at virtually any site that may be predisposed to bleeding. Includes cerebral hemorrhage, gallbladder hemorrhage, hematuria, hemophthalmos, hepatic hemorrhage, melena, menorrhagia, metrorrhagia
Hepatic: Hepatotoxicity
