DesOwen® (desonide cream, ointment and lotion) Cream 0.05%, Ointment 0.05%, and Lotion 0.05% contain desonide (Pregna-1,4-diene-3,20-dione,11,21-dihydroxy- 16,17-[(1-methylethylidene)bis(oxy)]-,(11 β ,16 α )- a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as antiinflammatory and anti-pruritic agents.
Chemically, desonide is C24H32O6. It has the following structural formula:
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Desonide has the molecular weight of 416.51. It is a white to off white odorless powder which is soluble in methanol and practically insoluble in water.
Each gram of DesOwen® (desonide cream, ointment and lotion) Cream contains 0.5 mg of desonide in a base of citric acid, emulsifying wax, isopropyl palmitate, polysorbate 60, potassium sorbate, propyl gallate, propylene glycol, purified water, sodium hydroxide, sorbic acid, stearic acid, and synthetic beeswax.
Each gram of DesOwen® (desonide cream, ointment and lotion) Ointment contains 0.5 mg of desonide in a base of mineral oil and polyethylene.
Each gram of DesOwen® (desonide cream, ointment and lotion) Lotion contains 0.5 mg of desonide in a base of cetyl alcohol, edetate sodium, glyceryl stearate SE, light mineral oil, methylparaben, propylene glycol, propylparaben, purified water, sodium lauryl sulfate, sorbitan monostearate, and stearyl alcohol. May contain citric acid and/or sodium hydroxide for pH adjustment.
