What is this drug used for?
• It is used to treat seizures.
• It may be given to you for other reasons. Talk with the doctor.
Frequently reported side effects of this drug
• Loss of strength and energy
• Fatigue
• Nausea
• Abdominal pain
• Headache
• Lack of appetite
• Diarrhea
• Trouble sleeping
Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:
• Severe sulfonamide reaction like rash; red, swollen, blistered, or peeling skin; red or irritated eyes; sores in your mouth, throat, nose, or eyes; fever, chills, or sore throat; cough that is new or worse; loss of strength and energy; any bruising or bleeding; or liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes
• Acidosis like confusion, fast breathing, fast heartbeat, arrhythmia, severe abdominal pain, nausea, vomiting, fatigue, shortness of breath, or feeling very tired or weak
• Depression like thoughts of suicide, anxiety, , agitation, irritability, panic attacks, mood changes, behavioral changes, or confusion
• Kidney stone like back pain, abdominal pain, or blood in the urine
• Change in balance
• Lack of sweat
• Persistent or high fever
• Persistent or high fever
• Sensing things that seem real but are not
• Seizures
• Trouble focusing
• Trouble speaking
• Vision changes
• Trouble with memory
• Bone pain
• Severe muscle pain
• Severe muscle weakness
• Swollen glands
• Chest pain
• Change in amount of urine passed
• Not passing urine
• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
Pronunciation
(zoe NIS a mide)
Medication Safety Issues
Sound-alike/look-alike issues:
Zonegran may be confused with SINEquan
Zonisamide may be confused with lacosamid.
Storage and Stability
Store at 25°C (77°F) excursions are permitted between 15°C and 30°C (59°F and 86°F). Protect from moisture and light.
Adverse Reactions
Central nervous system: Agitation, anxiety, ataxia, confusion, convulsions, decreased mental acuity, depression, dizziness, drowsiness, fatigue, headache, hyperesthesia, hyperthermia, hypotonia, insomnia, irritability, lack of concentration, memory impairment, nervousness, schizophreniform disorder, seizure, speech decreased, speech disturbance, status epilepticus, tiredness
Dermatologic: Bruising, hypohidrosis (children), pruritus, skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis
Endrocrine & metabolic: Metabolic acidosis
Gastrointestinal: Abdominal pain, anorexia, constipation, diarrhea, dysgeusia, dyspepsia, nausea, vomiting, weight loss, xerostomia
Hematologic & oncologic: Agranulocytosis, aplastic anemia
Neuromuscular & skeletal: Abnormal gait, paresthesia, tremor, weakness
Ophthalmic: Amblyopia, diplopia, nystagmus
Otic: Tinnitus
Renal: Increased blood urea nitrogen, nephrolithiasis
Respiratory: Increased cough, pharyngitis, rhinitis
Miscellaneous: Accidental injury, flu-like syndrome
Rare (but important or life threatening symptoms): Alopecia, amenorrhea, apnea, arthritis, atrial fibrillation, bladder calculus, bradycardia, brain disease, cardiac failure, cerebrovascular accident, cholangitis, cholecystitis, cholestatic jaundice, colitis, deafness, DRESS syndrome, duodenitis, fecal incontinence, gastrointestinal ulcer, gingivitis, glaucoma, hematemesis, hematuria, hemoptysis, hirsutism, hypermenorrhea, hypersensitivity reaction, hypertension, hypoglycemia, hyponatremia, hypotension, immunodeficiency, impotence, iritis, leukopenia, lupus erythematosus, lymphadenopathy, mastitis, neuropathy, oculogyric crisis, pancreatitis, photophobia, psychomotor disturbance, pulmonary embolism, rectal hemorrhage, stroke, suicidal behavior, suicidal ideation, syncope, thrombocytopenia, thrombophlebitis, urinary incontinence, ventricular premature contractions
